Background Dysregulation of the innate immune response to SARS-CoV-2 has been linked to poor outcomes in COVID-19. Neutrophils are key players in this response, displaying distinct functional profiles associated with disease severity. This study investigates how neutrophil phenotypes, and their mediators are modulated in severe COVID-19 following vaccination. Methods and Results We conducted an observational case-control study...

Brown adipose tissue (BAT) activity in humans is linked to better glucose metabolism and cardiometabolic health. In mice, cold exposure increases circulating succinate and enhances BAT thermogenesis, but whether similar succinate responses occur in humans remains undetermined. We analysed data from 33 young (18–25 years), sedentary adults (20 women) from the ACTIBATE cohort (NCT02365129). Plasma succinate was measured enzymati...

Cold exposure activates brown adipose tissue (BAT), a therapeutic target to mitigate cardiometabolic diseases. Emerging evidence suggests that bile acids may influence BAT activity through metabolic and endocrine signaling pathways. Characterizing changes in circulating bile acids during cold exposure may uncover new pathways to improve metabolic health in humans. We analysed 56 young (21.7 ± 2.3 years old), sedentary adults (...

The tie vectors at co-location sites are required for combining the individual space geodetic solutions and computing the International Terrestrial Reference Frame. Their provision to the combination centres entails a proper and accurate alignment of the tie vector into the global geocentric frame. In order to assess the impact of different alignment strategies on the space geodetic combination, we test four alignment approach...