R. M. Harding results 67
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Body size is a key trait in ecology due to its influence on metabolism and many other life‐history traits that affect population and community responses to environmental variation as well as ecosystem properties. The size spectrum represents the relationship between abundance (or biomass) and body size, independent of species identity. Size spectrum parameters, such as the slope or intercept, have been applied extensively as i...
Coronary microvascular disease (CMD) and its progression towards major adverse coronary events pose a significant health challenge. Accurate in vitro investigation of CMD requires a robust cell model that faithfully represents the cells within the cardiac microvasculature. Human pluripotent stem cell-derived endothelial cells (hPSC-ECs) offer great potential; however, they are traditionally derived via differentiation protocol...
MR Imaging in Ataxias: Consensus Recommendations by the Ataxia Global Initiative Working Group on MRI BiomarkersNARA Subscribed
With many viable strategies in the therapeutic pipeline, upcoming clinical trials in hereditary and sporadic degenerative ataxias will benefit from non-invasive MRI biomarkers for patient stratification and the evaluation of therapies. The MRI Biomarkers Working Group of the Ataxia Global Initiative therefore devised guidelines to facilitate harmonized MRI data acquisition in clinical research and trials in ataxias. Recommenda...
Fish and macroinvertebrate assemblages reveal extensive degradation of the world's riversNARA Subscribed
Rivers suffer from multiple stressors acting simultaneously on their biota, but the consequences are poorly quantified at the global scale. We evaluated the biological condition of rivers globally, including the largest proportion of countries from the Global South published to date. We gathered macroinvertebrate‐ and fish‐based assessments from 72,275 and 37,676 sites, respectively, from 64 study regions across six continents...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Introduced aquatic macrophytes can dominate small agricultural waterways in summer and autumn becoming a significant management problem. Excessive growth can clog waterways, causing drainage issues and reducing agricultural productivity while in‐stream velocities are reduced and sedimentation increased. Consequently, water managers remove them by mechanical clearance, chemical spray and cutting which can be costly and have neg...
Evaluating practical macrophyte control tools on small agricultural waterways in Canterbury, New ZealandNARA Subscribed
Excessive macrophytes can cause significant problems in agricultural waterways requiring active management. Conventional control techniques can have a range of adverse effects. We investigated several control tools in two experiments: firstly, we tested eight treatments at a small‐scale (2 m × 2 m). We found intensive hand weeding, weed mat and herbicide spraying to be effective treatments, reducing macrophyte cover to
Fishes in a changing world: learning from the past to promote sustainability of fish populationsNARA Subscribed
Populations of fishes provide valuable services for billions of people, but face diverse and interacting threats that jeopardize their sustainability. Human population growth and intensifying resource use for food, water, energy and goods are compromising fish populations through a variety of mechanisms, including overfishing, habitat degradation and declines in water quality. The important challenges raised by these issues ha...
A regime shift is a large, sudden, and long‐lasting change in the dynamics of an ecosystem, affecting multiple trophic levels. There are a growing number of papers that report regime shifts in marine ecosystems. However, the evidence for regime shifts is equivocal, because the methods used to detect them are not yet well developed. We have collated over 300 biological time series from seven marine regions around the UK, coveri...