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Physics-based 3D ground motion simulations of the 1703 L’Aquila earthquake: from historical reconstruction to seismic scenariosNARA Subscribed
The city of L’Aquila (central Italy) and its surrounding villages have been struck several times throughout history by strong earthquakes, most recently by the $$M_w$$ M w 6.1 event of April 6, 2009. Previously, on February 2, 1703, L’Aquila was partially destroyed by a $$M_w$$ M w 6.7 earthquake, which has remained in the city’s collective memory as the Grande Terremoto (“Big Earthquake”). In this paper, we present a physics-...
Coral mortality in a mass bleaching event influenced by proximity to diseased tissue and reef topographyNARA Subscribed
Coral reefs of the Florida Keys experienced the hottest summer on record in 2023, causing mass bleaching and mortality of scleractinian corals. Sea surface temperatures remained above 31°C for 41 days, exceeding all prior records for the region. Branching corals fared especially poorly, especially Acropora palmata , which has now been deemed functionally extinct across the entire Florida Reef Tract. High temperatures and prolo...
Introduction Coral reefs of Guadeloupe have undergone substantial ecological degradation over the past decade, driven by cumulative disturbances including mass bleaching events, the emergence of Stony Coral Tissue Loss Disease (SCTLD), repeated Diadema antillarum die-offs and recurrent cyclones. Methods A 10-year dataset (2014-2024), from the European Water Framework Directive, combining physicochemical measurements, benthic c...
Multimorbidity as a predictor of mortality in companion dogsNARA Subscribed
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Whole blood transcriptional signatures of age and survival identified in long life family and integrative longevity omics studiesNARA Subscribed
Although aging is a universal event, some individuals are able to achieve extreme longevity. The Long-Life Family Study (LLFS) enrolls participants from families enriched with long-lived individuals, serves as a valuable dataset for studying ageing phenotypes and identify potential intervention targets. We analyzed the association between age at blood draw and 16,284 RNAseq-based blood transcriptomic data from 2,167 LLFS parti...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The increasing feasibility of whole‐genome sequencing has been highly anticipated, promising to transform our understanding of the biology of nonmodel species. Notably, dramatic cost reductions beginning around 2007 with the advent of high‐throughput sequencing inspired publications heralding the ‘genomics revolution’, with predictions about its future impacts. Although such predictions served as useful guideposts, value is ad...