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Nicotinamide riboside supplementation restores microglial health and improves cognition in aged male miceNARA Subscribed
Cognitive impairment affects 1 in 6 individuals over 60, with over 75 million projected by 2030. Age-related changes in microglial function and declining nicotinamide adenine dinucleotide (NAD + ) levels may contribute to cognitive decline. Although nicotinamide riboside (NR) supplementation can restore NAD + levels in aged mice, its effects on microglial phenotype and cognition during normal aging remain unclear. We assessed...
Chronic inflammation mediates the relationship between physical activity and telomere lengthNARA Subscribed
A physically active lifestyle benefits cellular aging, however the mechanisms linking physical activity (PA) with longevity remain unclear. PA is associated with longer telomere length (TL), while shorter TL has been associated with increased cellular aging. Some research suggests increased levels of inflammatory markers, such as C-reactive protein (CRP), are associated with telomere dysfunction. We tested the hypothesis that...