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Subnational entities such as states and provinces differ markedly in their material use, waste generation, and emissions due to variations in resource endowments, industrial structures, and living standards. These differences create distinct sustainability challenges that require regionally tailored policy responses. Yet, the development of comprehensive subnational datasets and indicators, including circular-economy metrics,...
History of episodic heavy alcohol use predicts antidepressant effectiveness of ketamineNARA Subscribed
Rationale Antidepressant response to ketamine is greatest in patients with a family history of alcohol use disorder (AUD), but it remains unclear if this trend holds true for a personal history of alcohol use. Objective We hypothesized that a personal history of episodic heavy drinking would positively correlate with antidepressant response to ketamine. Methods In a retrospective cohort study, patients with Major Depressive Di...
Soil Microbial Diversity and Network Organization Respond to Land Use and Agricultural Inputs WorldwideNARA Subscribed
Soil microbiomes are critical for ecosystem functioning, yet the global influences of climate and agricultural practices on their diversity and structure remain incompletely characterized. Here we analyzed 1921 soil samples from 33 countries worldwide across diverse biomes to assess how climate gradients and agricultural inputs, including pesticides and fertilizers, shape prokaryotic and fungal communities. We found that micro...
Microbiome and Pathobiome Characterization in Farmed Barramundi ( Lates calcarifer ) During and Post Scale Drop Disease OutbreaksNARA Subscribed
Large‐scale double‐digest RAD sequencing (ddRADseq) datasets generated for genotyping are increasingly available in aquaculture, yet their unmapped reads remain largely unexplored for pathogen surveillance. Here, we evaluated the utility and limitations of repurposing unmapped ddRADseq reads to examine pathogen‐associated and disease‐associated microbiome‐pathobiome patterns during scale drop disease (SDD) outbreaks in farmed...
Main conclusion Almond trees prioritize C to yield rather than stem growth, and their overall lower NSC stores compared to forest trees may have consequences for resilience under environmental variability. Abstract Perennial tree crops store nonstructural carbohydrates (NSCs) as energy reserves that can be used to persist during both predictable periods of reduced activity like dormancy and more unpredictable periods associate...
Inoculation with arbuscular mycorrhizal fungi can increase the concentration of per and poly-fluoroalkyl substances in cereal cropsNARA Subscribed
Contamination of agricultural soils with per- and poly-fluoroalkyl substances (PFAS) is now widespread and common throughout the world due to management practices such as biosolid application. Crop and pasture plants can readily take up and accumulate PFAS in their tissues, which eventually end up in food products or livestock feed and lead to health issues. This study investigated how arbuscular mycorrhizal (AM) fungi affect...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Small Molecules to Elevate Rab7-GTPase Activity and Lower Cholesterol Accumulation in Niemann-Pick Type C DiseaseNARA Subscribed
Purpose Niemann-Pick type C (NPC) disease caused by mutations in cholesterol transporters NPC1 or NPC2 is characterized by cholesterol accumulation in late endosomes/lysosomes (LE/Lys). The activation of alternative cholesterol export routes that can bypass NPC1/2 deficiency could provide therapeutic opportunities. We previously demonstrated that gene depletion of the Rab7-GTPase activating protein (GAP) TBC1D15, which hydroly...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...