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Population Genomics of a Cosmopolitan Weed Provides Insights Into Its Local Adaptation and Recent Demographic HistoryNARA Subscribed
Invasive plant species present a growing ecological and economic challenge, and often adapt rapidly to their novel environments through complex demographic and evolutionary processes. Invasion genomics offers powerful tools to disentangle these processes, but most studies rely on geographically narrow sampling across native and non‐native ranges. Erigeron canadensis is a cosmopolitan weed native to North America that has succe...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Prediction of bone ingrowth into the porous swelling bone anchors using an osteoconnectivity-based adaptive finite element algorithmNARA Subscribed
In this study, a bone ingrowth framework was developed, which was integrated with a hygro-elastic swelling simulation, to evaluate the ingrowth of bone into porous co-polymeric swelling bone anchors. The aim was to investigate the impact of swelling-induced radial stress on bone ingrowth and the improvement in the mechanical properties and fixation strength of the anchors. Using the finite element method coupled with the osteo...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Remotely Sensed Fire Heterogeneity and Biomass Recovery Predicts Empirical Biodiversity ResponsesNARA Subscribed
Aim To compare field‐based evidence of plant and animal responses to fire with remotely sensed signals of fire heterogeneity and post‐fire biomass recovery. Location South‐eastern Australia; New South Wales. Time Period 2019–2022. Major Taxa Studied A total of 982 species of plants and animals, in eight taxonomic groups: amphibians, birds, fish, insects, mammals, molluscs, plants and reptiles. Methods We collated 545,223 plant...
Extreme Drought Increases the Temporal Variability of Grassland Productivity by Suppressing Dominant GrassesNARA Subscribed
Extreme droughts are intensifying, yet their impact on temporal variability of grassland functioning and its drivers remains poorly understood. We imposed a 6‐year extreme drought in two semiarid grasslands to explore how drought influences the temporal variability of ANPP and identify potential stabilising mechanisms. Drought decreased ANPP while increasing its temporal variability across grasslands. In the absence of drought...
Demographic change and loss of big trees in resprouting eucalypt forests exposed to megadisturbanceNARA Subscribed
Aim Increased tree mortality linked to droughts and fires is occurring across temperate regions globally. Vegetation recovery has been widely reported; however, less is known about how disturbance may alter forests structurally and functionally across environmental gradients. We examined whether dry forests growing on low‐fertility soils were more resilient to coupled extreme drought and severe fire owing to lower tree mortali...
Co-production of models to evaluate conservation alternatives for a threatened fish in a rapidly changing landscapeNARA Subscribed
Reintroductions are one means of managing species distributions, but the feasibility of such efforts is uncertain. Here we consider reintroduction for threatened bull trout ( Salvelinus confluentus ) that currently occupy a small fraction of historically occupied habitats in the upper Klamath River basin owing to climate warming and human modifications of ecosystems. We engaged stakeholders across multiple organizations to co-...