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Analysis of genetic risk factors for Leber hereditary optic neuropathy in the Polish populationNARA Subscribed
Leber hereditary optic neuropathy (LHON) is primarily caused by pathogenic mitochondrial DNA (mtDNA) variants, most commonly the m.11778G>A variant in the MT-ND4 gene. The presence of this variant alone is insufficient to trigger disease symptoms, of which vision loss is the hallmark. Given the incomplete penetrance and inter-population variability in modifying factors, this study aimed to investigate two previously proposed g...
LARES-2 contribution to global geodetic parameters from the combined LAGEOS-LARES solutionsNARA Subscribed
LARES-2 is a new geodetic satellite designed for high-accuracy satellite laser ranging. The orbit altitude of LARES-2 is similar to that of LAGEOS-1, whereas the inclination angle of 70° complements the LAGEOS-1 inclination of 110°; hence, both satellites form the butterfly configuration for the verification of the Lense–Thirring effect. Although the major objective of LARES-2 is testing general relativity, LARES-2 substantial...
Host–pathogen interactions under pressure: A review and meta‐analysis of stress‐mediated effects on disease dynamicsNARA Subscribed
Human activities have increased the intensity and frequency of natural stressors and created novel stressors, altering host–pathogen interactions and changing the risk of emerging infectious diseases. Despite the ubiquity of such anthropogenic impacts, predicting the directionality of outcomes has proven challenging. Here, we conduct a review and meta‐analysis to determine the primary mechanisms through which stressors affect...
Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergyNARA Subscribed
Purpose Ongoing angiogenesis renders the tumor endothelium unresponsive to inflammatory cytokines and interferes with adhesion of leukocytes, resulting in escape from immunity. This process is referred to as tumor endothelial cell anergy. We aimed to investigate whether anti-angiogenic agents can overcome endothelial cell anergy and provide pro-inflammatory conditions. Experimental design Tissues of renal cell carcinoma (RCC)...
Prevalence of epitheliocystis in freshwater Atlantic salmon reared in flow‐through and recirculation aquaculture systemsNARA Subscribed
Epitheliocystis, an intracellular bacterial infection in the gills and skin epithelium, has been frequently reported in Atlantic salmon ( Salmo salar ) during freshwater production in a number of countries. This study describes the prevalence and intensity of a natural epitheliocystis infection present in the gills of two strains of Atlantic salmon reared in either a flow‐through (FT) or a recirculation aquaculture system (RAS...
Distance decay 2.0 – A global synthesis of taxonomic and functional turnover in ecological communitiesNARA Subscribed
Aim Understanding the variation in community composition and species abundances (i.e., β‐diversity) is at the heart of community ecology. A common approach to examine β‐diversity is to evaluate directional variation in community composition by measuring the decay in the similarity among pairs of communities along spatial or environmental distance. We provide the first global synthesis of taxonomic and functional distance decay...
Functional traits offer a rich quantitative framework for developing and testing theories in evolutionary biology, ecology and ecosystem science. However, the potential of functional traits to drive theoretical advances and refine models of global change can only be fully realised when species‐level information is complete. Here we present the AVONET dataset containing comprehensive functional trait data for all birds, includi...
sPlotOpen – An environmentally balanced, open‐access, global dataset of vegetation plotsNARA Subscribed
Motivation Assessing biodiversity status and trends in plant communities is critical for understanding, quantifying and predicting the effects of global change on ecosystems. Vegetation plots record the occurrence or abundance of all plant species co‐occurring within delimited local areas. This allows species absences to be inferred, information seldom provided by existing global plant datasets. Although many vegetation plots...
Experimental exposure to low concentrations of Neoparamoeba perurans induces amoebic gill disease in Atlantic salmonNARA Subscribed
Amoebic gill disease (AGD) is a significant issue in Atlantic salmon mariculture. Research on the development of treatments or vaccines uses experimental challenges where salmon is exposed to amoebae concentrations ranging from 500 to 5,000/L. However, the water concentrations of N. perurans on affected salmon farms are much lower. The lowest concentration of N. perurans previously reported to cause AGD was 10/L. Here, we repo...
Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder with symptoms limited to a single tissue, optic nerve, resulting in vision loss. In the majority of cases it is caused by one of three point mutations in mitochondrial DNA (mtDNA) but their presence is not sufficient for disease development, since ~50% of men and ~10% women who carry them are affected. Thus additional modifying factors must exist. In this stu...