The study of a desmoglein 2 murine model of arrhythmogenic cardiomyopathy revealed cardiac inflammation as a key early event leading to fibrosis. Arrhythmogenic cardiomyopathy (AC) is an inherited heart muscle disorder leading to ventricular arrhythmias and heart failure due to abnormalities in the cardiac desmosome. We examined how loss of desmoglein 2 ( Dsg2 ) in the young murine heart leads to development of AC. Apoptosis w...

Key message A unique, global onion diversity set was assembled, genotyped and phenotyped for beneficial traits. Accessions with strong basal rot resistance and increased seedling vigour were identified along with associated markers. Abstract Conserving biodiversity is critical for safeguarding future crop production. Onion ( Allium cepa L.) is a globally important crop with a very large (16 Gb per 1C) genome which has not been...