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White spot syndrome, caused by the white spot syndrome virus (WSSV), is a devastating viral disease responsible for significant economic losses in the shrimp farming industry. In the search for natural therapeutic alternatives against WSSV, this study explored the antiviral potential of portoamides, natural peptides produced by the cyanobacterium Phormidium sp. LEGE 05292. Given that the structural proteins of the viral envelo...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...