This study aimed to evaluate the potential cost-effectiveness of implementing a prediction tool for estimating mild cognitive impairment (MCI) to dementia conversion risk. A decision-analytic model was developed to compare the costs and effects of current practice for subjects with MCI to a situation in which the risk of dementia is estimated using a prediction tool. Different scenarios in terms of prediction horizons, predict...

Anthropogenic impacts are increasingly affecting deep‐sea environments, including seafloor sediment disturbances by bottom trawling and seafloor mining. Fieldwork in the ‘Resilience Of Benthic Ecosystems to Sedimentation’ (ROBES) project were conducted in 2018–2020 on the 400 m‐deep Chatham Rise crest, eastern Aotearoa New Zealand. Water column turbidity data, sediment traps on near‐seabed moorings and benthic landers and surf...

Key message Potato bolters are caused by excision of a transposon from the StCDF1.3 allele, resulting in a somatic mutant with late maturity . Abstract Somatic mutations during vegetative propagation can lead to novel genotypes, known as sports. In cultivated potato ( Solanum tuberosum ), a recurring sport type, called ‘Bolters’, is characterized by vigorous haulms and prolonged flowering. Bolters emerge spontaneously during p...

Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were administered in the diet ad libitum beginning at 7 months of age. In male mice, EPI increased median lifespan by ~ 5%, and HAL and MIT each increased median lifespan by ~ 9%. EPI and HAL, but...

Reference genomes from representative species across families provide the critical infrastructure for research and conservation. The Cetacean Genomes Project (CGP) began in early 2020 to facilitate the generation of near error-free, chromosome-resolved reference genomes for all cetacean species. Towards that goal, and using the methods, goals and genome assembly quality standards of the Vertebrate Genomes Project (VGP), we gen...

This work focusses on extending the deep compartment model (DCM) framework to the estimation of mixed-effects. By introducing random effects, model predictions can be personalized based on drug measurements, enabling the testing of different treatment schedules on an individual basis. The performance of classical first-order (FO and FOCE) and machine learning based variational inference (VI) algorithms were compared in a simul...