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Acetamiprid (ACE) is a widely used neonicotinoid insecticide with known neurotoxic potential, for which the European Food Safety Authority lowered the acceptable daily intake. Current physiologically-based kinetic (PBK) models lack adequate kinetic data for ACE and its metabolite acetamiprid-N-desmethyl (ACE-DEM). The aim of this study was to generate detailed disposition data for ACE in a controlled volunteer setting to devel...
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