R. Schmidt results 548
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Characterization of compositional endmembers in PIXL scansNARA Subscribed
Discovery of a Potent Small Molecule Antagonist of GRPR for the Treatment of PruritusNARA Subscribed
Persistent pruritus (itch) affects the quality of life, and many itch syndromes remain untreatable. Previously, we identified the gastrin-releasing peptide receptor (GRPR) playing a critical role in mediating histamine-independent itch signaling. In this study, we aimed to identify small-molecule GRPR antagonists to treat histamine-independent itch. Starting with the known small-molecule GRPR antagonist PD 176,252, we conducte...
As the climate warms and sea ice continues to melt, an increase in overall shipping traffic to the Arctic and to local communities is expected. Specifically, an increase in cruise ship traffic has led to higher numbers of visitors to the Arctic and sub-Arctic. As a secondary effect of increased human activity in this region, invasive species prevention and removal will become a priority, especially as species’ ranges continue...
The aging epigenome: integrative analyses reveal intersection with Alzheimer’s diseaseNARA Subscribed
Aging is the strongest risk factor for Alzheimer’s disease (AD), yet the role of age-associated DNA methylation (DNAm) changes in blood and their relevance to AD remains poorly understood. We performed a meta-analysis of blood DNAm samples from 475 dementia-free subjects aged over 65 years across two independent cohorts, the Framingham Heart Study (FHS) at Exam 9 and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We a...
Integrated Reanalysis of Global Riverine Fish eDNA Datasets Shows Robustness and Congruence of Biodiversity ConclusionsNARA Subscribed
The analysis of environmental DNA (eDNA) has revolutionized biodiversity assessments in aquatic ecosystems, enabling non‐invasive monitoring of fish communities across diverse regions. However, the global comparability of these eDNA datasets remains ambiguous due to heterogeneous sampling protocols and bioinformatic workflows across studies, making it difficult to assess how robust and comparable the biodiversity patterns infe...
Local and Landscape‐Level Environmental Conditions Drive Habitat Selection Across Terrestrial Mammal SpeciesNARA Subscribed
Aim Animal movements are a fundamental process affecting communities and ecosystems. Quantifying habitat selection across species and habitats is key for understanding how animals respond to environmental change. Currently, we lack comparative studies that examine how habitat selection varies across species traits and landscapes. We aim to quantify global patterns of habitat selection to help understand the fundamental drivers...
Genetic monitoring reveals loss of genetic variation and increased isolation in an endangered pond-breeding amphibianNARA Subscribed
Empirical knowledge on how genetic diversity changes through time in populations in the wild is extremely limited. This study aims to contribute toward a better understanding of the dynamics of genetic diversity over time in an amphibian species Red-Listed as endangered in Switzerland, the natterjack toad, Epidalea calamita , which lives along the Swiss Reuss valley, an area Dominated by human activity. We collected samples in...