The abnormal tumor vasculature can present a barrier to the infiltration of anti-tumor immune cells, which impairs immune surveillance and response to immunotherapy. Here, we show that genetically deleting the epigenetic factor DNA methyltransferase 1 ( Dnmt1 ) in endothelial cells (ECs) reduces angiogenesis while imparting profound changes to the tumor immune microenvironment (TIME), including increased proportions of CD4 + m...

Heavy metal (HM) contamination in marine sediments is a critical environmental concern due to its potential ecological and human health impacts. This study provides a comprehensive assessment of the spatial and temporal evolution of HM contamination in Arabian Gulf sediments over a 33-year period (1991–2024). Contamination levels were evaluated using key sediment quality indices such as the contamination factor (CF), geoaccumu...