HLA-B*57 affects the course of HIV infection. Under antiretroviral therapy, its effects cannot be explained by outstandingly efficient T cell responses alone but may also involve cells of innate immunity. Studying in vitro stimulation with Pam3CSK4, E. coli LPS-B5 and CpG-ODN-2216, we observed greater induction of IL-6/IL-1beta double-positive CD14 + CD16 ++ monocytes as well as IFN-gamma-positive cytotoxic CD56 high CD16 neg...

Marked changes in sediment types deposited in Cabin Lake, near Cordova, Alaska, represent environmental shifts during the early and late Holocene, including fluctuations in the terminal position of Sheridan Glacier. Cabin Lake is situated to receive meltwater during periods when the outwash plain of the advancing Sheridan Glacier had aggraded. A brief early Holocene advance from 11.2 to 11.0 cal ka is represented by glacial ro...

Conservationists often advocate for landscape approaches to wildlife management while others argue for physical separation between protected species and human communities, but direct empirical comparisons of these alternatives are scarce. We relate African lion population densities and population trends to contrasting management practices across 42 sites in 11 countries. Lion populations in fenced reserves are significantly cl...