R. de Groot results 54
· Newest (Page 1/3, per page 25)
Author: R. de Groot ×Clear All Filters
Search Results
The largest light-harvesting antenna in nature, the chlorosome, is a heterogeneous helical BChl self-assembly that has evolved in green bacteria to harvest light for performing photosynthesis in low-light environments. Guided by NMR chemical shifts and distance constraints for Chlorobaculum tepidum wild-type chlorosomes, the two contrasting packing modes for syn-anti parallel stacks of BChl c to form polar 2D arrays, with dipo...
We aim to elucidate how miRNAs regulate the mRNA signature of atrial fibrillation (AF), to gain mechanistic insight and identify candidate targets for future therapies. We present combined miRNA–mRNA sequencing using atrial tissues of patient without AF ( n = 22), with paroxysmal AF ( n = 22) and with persistent AF ( n = 20). mRNA sequencing previously uncovered upregulated epithelial to mesenchymal transition, endothelial cel...
Seventy five percent of the world's food crops benefit from insect pollination. Hence, there has been increased interest in how global change drivers impact this critical ecosystem service. Because standardized data on crop pollination are rarely available, we are limited in our capacity to understand the variation in pollination benefits to crop yield, as well as to anticipate changes in this service, develop predictions, and...
This study evaluated the effectiveness of selective digestive tract decontamination (SDD) application three times daily (t.i.d.) compared to the standard four times daily (q.i.d.). Retrospective equivalence (combined non-inferiority and non-superiority design) study with a before-and-after design on a tertiary ICU in which the SDD frequency was reduced from q.i.d. to t.i.d. All patients with ICU admissions ≥72h and with ≥2 sur...
Reversible thrombocytopenia during hibernation originates from storage and release of platelets in liver sinusoidsNARA Subscribed
Immobility is a risk factor for thrombosis due to low blood flow, which may result in activation of the coagulation system, recruitment of platelets and clot formation. Nevertheless, hibernating animals—who endure lengthy periods of immobility—do not show signs of thrombosis throughout or after hibernation. One of the adaptations of hemostasis in hibernators consists of a rapidly reversible reduction of the number of circulati...
Evolution of HLA-F and its orthologues in primate species: a complex tale of conservation, diversification and inactivationNARA Subscribed
HLA-F represents one of the nonclassical MHC class I molecules in humans. Its main characteristics involve low levels of polymorphism in combination with a restricted tissue distribution. This signals that the gene product executes a specialised function, which, however, is still poorly understood. Relatively little is known about the evolutionary equivalents of this gene in nonhuman primates, especially with regard to populat...
The effectiveness of flower strips and hedgerows on pest control, pollination services and crop yield: a quantitative synthesisNARA Subscribed
Floral plantings are promoted to foster ecological intensification of agriculture through provisioning of ecosystem services. However, a comprehensive assessment of the effectiveness of different floral plantings, their characteristics and consequences for crop yield is lacking. Here we quantified the impacts of flower strips and hedgerows on pest control (18 studies) and pollination services (17 studies) in adjacent crops in...
Modulating local airway immune responses to treat allergic asthma: lessons from experimental models and human studiesNARA Subscribed
With asthma affecting over 300 million individuals world-wide and estimated to affect 400 million by 2025, developing effective, long-lasting therapeutics is essential. Allergic asthma, where Th2-type immunity plays a central role, represents 90% of child and 50% of adult asthma cases. Research based largely on animal models of allergic disease have led to the generation of a novel class of drugs, so-called biologicals, that t...
Correction to: Strategic crossing of biomass and harvest index—source and sink—achieves genetic gains in wheatNARA Subscribed
The original article was corrected. Author Muhammad Kundi should instead read: Muhammad Sohail.
Strategic crossing of biomass and harvest index—source and sink—achieves genetic gains in wheatNARA Subscribed
To accelerate genetic gains in breeding, physiological trait (PT) characterization of candidate parents can help make more strategic crosses, increasing the probability of accumulating favorable alleles compared to crossing relatively uncharacterized lines. In this study, crosses were designed to complement “source” with “sink” traits, where at least one parent was selected for favorable expression of biomass and/or radiation...
No postcopulatory selection against MHC ‐homozygous offspring: Evidence from a pedigreed captive rhesus macaque colonyNARA Subscribed
The heterozygosity status of polymorphic elements of the immune system, such as the major histocompatibility complex ( MHC ), is known to increase the potential to cope with a wider variety of pathogens. Pre‐ and postcopulatory processes may regulate MHC heterozygosity. In a population where mating occurs among individuals that share identical MHC haplotypes, postcopulatory selection may disfavour homozygous offspring or ones...