R.J. Hall results 261
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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Multichemical Exposure Assessment Using Silicone Wristbands in Central American AdolescentsNARA Subscribed
Chemical exposures are poorly characterized in Central America, where chronic kidney disease of uncertain etiology (CKDu) is a leading cause of death. Most research evaluates occupational exposures in adults, yet early-life exposures remain understudied. We used silicone wristband passive samplers to characterize exposure to over 1,500 chemicals among Nicaraguan adolescents ( n = 80) residing in CKD high-risk communities but n...
Aim The Indo‐Pacific is the world's largest marine biogeographic region. It is characterised by different degrees of connectivity among its subregions and harbours the majority of demosponge species currently known to science. Comparisons between regional sponge faunas have been undertaken in the past, mostly based on morphological species identification. The Sponge Barcoding Project, in tandem with regional DNA taxonomy campa...
Local and Landscape‐Level Environmental Conditions Drive Habitat Selection Across Terrestrial Mammal SpeciesNARA Subscribed
Aim Animal movements are a fundamental process affecting communities and ecosystems. Quantifying habitat selection across species and habitats is key for understanding how animals respond to environmental change. Currently, we lack comparative studies that examine how habitat selection varies across species traits and landscapes. We aim to quantify global patterns of habitat selection to help understand the fundamental drivers...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
A balanced approach to the potential of octopus aquacultureNARA Subscribed
Management considerations for establishing a coastal acidification monitoring system from U.S. Coastal Acidification NetworksNARA Subscribed
Ocean acidification (OA), caused by the uptake of anthropogenic carbon dioxide, is a concern for ocean resource users in coastal regions where the phenomenon is compounded by variable processes. Sustained OA monitoring systems are critical for characterization of baseline ocean conditions and identification of changes and impacts to coastal ecosystems and communities. Establishing an OA monitoring network is best accomplished...
Discovering a predictive metabolic signature of drug-induced structural cardiotoxicity in cardiac microtissuesNARA Subscribed
Improved prediction of drug-induced structural cardiotoxicity is required to reduce attrition driven by cardiac safety concerns in drug discovery. Omics measurements are well suited to this need, offering the potential to discover molecular signatures associated with toxicological endpoints. In addition, untargeted metabolomics can simultaneously measure xenobiotic fate within the test system. We present an extensive metabolom...
Radium isotopes quantify vertical mixing and reveal large benthic silicate fluxes in anoxic deep watersNARA Subscribed
Benthic fluxes are important sources of nutrients and dissolved carbon to the water column. Yet, most approaches for quantifying benthic fluxes are labor intensive and cover relatively small areas of the ocean. Here, we use 224 Ra to quantify ecosystem‐scale vertical mixing across a largely hypoxic deep water column in the Baltic Sea and related benthic Si fluxes. Bottom water profiles from 50 stations along a ~ 5000 km cruise...