R.P. Davis results 144
· Newest (Page 1/6, per page 25)
Author: R.P. Davis ×Clear All Filters
Search Results
Constructed value of information (CVoI) is an expert elicitation decision‐analytic tool used to prioritize sources of uncertainty based on their potential to improve decision outcomes if resolved. Despite increased application of CVoI, the robustness of CVoI prioritization of sources of uncertainty relative to differences in expert elicitation and scoring methods has not been evaluated. We engaged a group of species experts in...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The proportion of individuals that are found to have empty stomachs during a survey of a predator population's diet has been used as an indicator of the average individual's state of energy balance and of the degree to which its feeding rate (i.e., its functional response) is saturated with respect to prey availability. As such, the proportion of empty stomachs provides insights into the effects of prey on predators and vice v...
Nicotinamide riboside supplementation restores microglial health and improves cognition in aged male miceNARA Subscribed
Cognitive impairment affects 1 in 6 individuals over 60, with over 75 million projected by 2030. Age-related changes in microglial function and declining nicotinamide adenine dinucleotide (NAD + ) levels may contribute to cognitive decline. Although nicotinamide riboside (NR) supplementation can restore NAD + levels in aged mice, its effects on microglial phenotype and cognition during normal aging remain unclear. We assessed...
The key mechanisms associated with the survival of Gulf toadfish, Opsanus beta , when in severe hypoxiaNARA Subscribed
Florida's shallow seagrass beds experience daily diurnal fluctuations in environmental oxygen, leading to hypoxic episodes (PO 2 −1 , ~6 kPa) that have increased in frequency and intensity in recent decades. The native Gulf toadfish ( Opsanus beta ) have been shown to employ a suite of adaptive cardiovascular, ventilatory and metabolic adjustments to survive moderate hypoxia, but little is known of the mechanisms used to survi...
Individuals of many species prefer to associate with familiar conspecifics from their established social group over unfamiliar conspecifics. Such familiarity preferences are thought to be adaptive and have been documented widely in many social fishes. Zebrafish ( Danio rerio ) are extensively studied, highly social fish that form stable shoals in the wild, however there is only mixed evidence for familiarity preferences in thi...
The Greatest Extinction Event in 66 Million Years? Contextualising Anthropogenic ExtinctionsNARA Subscribed
Biological communities are changing rapidly in response to human activities, with the high rate of vertebrate species extinction leading many to propose that we are in the midst of a sixth mass extinction event. Five past mass extinction events have commonly been identified across the Phanerozoic, with the last occurring at the end of the Cretaceous, 66 million years ago (Ma). However, life on Earth has always changed and evol...