Rachel Marks results 164
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Circulating T-cell phenotypes are influenced by prior Staphylococcus aureus exposure in hemodialysis patientsNARA Subscribed
Staphylococcus aureus bloodstream infections are a significant risk for hemodialysis patients, who would significantly benefit from a preventative vaccine. To-date S. aureus vaccine trials have failed, in part due to lack of consideration of pre-existing immune imprints in relevant patient cohorts. Using a machine learning algorithm this study revealed, prior S. aureus exposure in a cohort of 180 hemodialysis patients, was ass...
Diversity and functional group composition drive biogeographic patterns in marine biogenic structural complexityNARA Subscribed
Biogenic structural complexity is a key driver of biodiversity and ecosystem functioning, yet its ecological and environmental determinants remain poorly understood across broad biogeographic scales. Here, we conducted standardized 90‐day field experiments at 16 coastal sites, spanning a 41‐degree latitudinal gradient, using naturally assembled marine fouling communities on settlement panels. We measured rugosity as our metric...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
The transformation-mainstreaming conundrum: Making sense of tensions in adaptation practiceNARA Subscribed
As the scale of climate change impacts become apparent, organisations globally are seeking to adapt. They face dual imperatives of transformation—going beyond business-as-usual to embrace disruptive changes to their decision-making processes—and mainstreaming—enacting adaptation initiatives with minimal change to existing capabilities and structures. In practice, these important imperatives can conflict, leading to the emergen...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Global interest in microplastics is increasing, with numerous organisations collecting data on microplastics in the environment. However, disparate sampling, analysis, and reporting methods limit our ability to integrate data, hindering a global understanding of microplastic occurrence, effects and dynamics. Drawing on international directives and collaborations, we present a comprehensive guideline of harmonised and standardi...
The study investigates the susceptibility of Atlantic salmon ( Salmo salar ) and Pacific salmon species (pink salmon, Oncorhynchus gorbuscha ; coho salmon, Oncorhynchus kisutch ; and chum salmon, Oncorhynchus keta ) to the parasitic salmon lice ( Lepeophtheirus salmonis ). The research had two main objectives: to characterize the morphology of the scaly skin in four salmonid species and to compare the cellular response at the...