Rachel Roberts results 239
· Newest (Page 1/10, per page 25)
Author: Rachel Roberts ×Clear All Filters
Search Results
A framework for identifying paper parksNARA Subscribed
Purpose Deepwater Horizon oil spill (DWHOS) responders potentially experienced multiple stressors. We examined associations between DWHOS deployment-related stressor patterns and neurological and endocrine/metabolic conditions among U.S. Coast Guard active duty responders who completed post-deployment surveys (n = 3102). Methods Deployment-related stressor patterns were identified using principal component analysis of self-rep...
Diversity and functional group composition drive biogeographic patterns in marine biogenic structural complexityNARA Subscribed
Biogenic structural complexity is a key driver of biodiversity and ecosystem functioning, yet its ecological and environmental determinants remain poorly understood across broad biogeographic scales. Here, we conducted standardized 90‐day field experiments at 16 coastal sites, spanning a 41‐degree latitudinal gradient, using naturally assembled marine fouling communities on settlement panels. We measured rugosity as our metric...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Purpose Mavacamten is the first targeted therapy for obstructive hypertrophic cardiomyopathy (oHCM). It is metabolised via cytochrome p450 enzymes, with variations in the CYP2C19 gene having predominant influence on plasma concentrations of mavacamten. We aimed to outline the effect of CYP2C19 metaboliser status on outcomes in patients taking mavacamten. Methods We retrospectively analysed clinical and echocardiographic data i...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...