The blood–brain barrier (BBB) is a stringent barrier that restricts the successful brain delivery of polar neurotherapeutics molecules. One such molecule is Zonisamide (ZNS), a hydrophilic centrally acting anti-epileptic drug. This study aims to overcome the poor ZNS BBB permeability using the nose-to-brain (NTB) carbon-based biocompatible nanodiamonds (ND) delivery system to deliver ZNS directly to the brain, bypassing the BB...

Titanium dioxide nanoparticles (TiO₂-NPs) are used widely in various industries, but emerging evidence suggests their ability to elicit neurotoxicity. The present study evaluated the alpha-lipoic acid (ALA) neuroprotective potential against TiO₂-NP-induced cognitive and molecular impairments in male Sprague–Dawley rats. Twenty-four rats were allocated into four groups: negative control, TiO₂-NPs (150 mg/kg, i.p.), ALA (50 mg/k...

As offshore wind turbines develop into deepwater operations, accurately quantifying the impact of stochastic excitation in complex sea environments on offshore wind turbines and conducting structural fatigue reliability analysis has become challenging. In this paper, based on long-term wind–wave reanalysis data from the South China Sea, a novel direct probability integral method (DPIM) is developed for the stochastic response...

Brain-specific angiogenesis inhibitor 1 (BAI1) belongs to the adhesion G-protein-coupled receptors, which exhibit large multi-domain extracellular N termini that mediate cell–cell and cell–matrix interactions. To explore the existence of BAI1 isoforms, we queried genomic datasets for markers of active chromatin and new transcript variants in the ADGRB1 (adhesion G-protein-coupled receptor B1) gene. Two major types of mRNAs wer...