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Five years of national airborne pollen monitoring in South Africa: biome-specific calendars to inform allergy diagnosis and preventionNARA Subscribed
Pollen monitoring is crucial for understanding seasonal patterns, supporting allergy diagnosis and informing early warning tools to mitigate allergic diseases. The Southern Hemisphere lacks long-term pollen seasonal data, with extremely few records from Africa. We present pollen calendars based on five years of data from South Africa. Airborne pollen from 2019 to 2024 across South African biomes was collected in seven cities u...
The function importance of serine threonine phosphatases (PP) in the heart is still subject of investigations. For instance, PP5 and PP2C occur in the human heart. It is unclear how they interact in the human heart. In order to obtain a model system, we have crossbred mice with heart-specific overexpression of PP2C or PP5 to obtain wild-type mice (WT), PP2C transgenic mice (PP2C-TG), PP5 transgenic mice (PP5-TG), and PP2CxPP5...
(R)-N 6 -Phenylisopropyladenosine (R-PIA), an agonist at A 1 -adenosine receptors, per se leads to so-called “direct” negative inotropic effects (NIE) in mammalian atrium. These NIE in mammalian atrium are often accentuated in the presence of cAMP-increasing agonists acting through GTP-binding stimulatory proteins in the sarcolemma such as isoprenaline (via β-adrenoceptors), histamine (via H 2 -histamine receptors) or serotoni...
Terrigenous inputs link nutrient dynamics to microbial communities in a tropical lagoonNARA Subscribed
Nutrient availability drives community structure and ecosystem processes, especially in tropical lagoons that are typically oligotrophic but often receive allochthonous inputs from land. Terrestrially derived nutrients are introduced to tropical lagoons by surface runoff and submarine groundwater discharge, which are influenced by seasonal precipitation. However, terrigenous inputs presumably diminish along the onshore–offshor...
N 6 -(R)-Phenylisopropyladenosine (R-PIA), an agonist at A 1 -adenosine receptors, alone exerts negative inotropic effects (NIE) in the human atrium. This NIE is augmented in the presence of cAMP-increasing agonists like phosphodiesterase inhibitors (cilostamide, rolipram) or a direct activator of adenylyl cyclase (forskolin). Cantharidin inhibits protein phosphatases 1 and 2A (PP1, PP2A). We hypothesized that cantharidin woul...
Prevalence of aeroallergen sensitization in a polluted and industrialized area: a pilot study in South Africa’s Vaal TriangleNARA Subscribed
This pioneering study evaluates the prevalence of aeroallergens reactivity among atopic populations living in the Vaal Triangle Airshed Priority Area (VTAPA), South Africa. A total of 138 volunteers (51 males and 87 females), of African, colored, white, and Asian ethnicity, and with a mean (range) age of 22 (18–56) years were participating in the study. The study was conducted on the North-West University (NWU) campus in Vande...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
Cantharidin and sodium fluoride attenuate the negative inotropic effects of carbachol in the isolated human atriumNARA Subscribed
Carbachol, an agonist at muscarinic receptors, exerts a negative inotropic effect in human atrium. Carbachol can activate protein phosphatases (PP1 or PP2A). We hypothesized that cantharidin or sodium fluoride, inhibitors of PP1 and PP2A, may attenuate a negative inotropic effect of carbachol. During bypass-surgery trabeculae carneae of human atrial preparations (HAP) were obtained. These trabeculae were mounted in organ baths...
Persistent net release of carbon dioxide and methane from an Alaskan lowland boreal peatland complexNARA Subscribed
Permafrost degradation in peatlands is altering vegetation and soil properties and impacting net carbon storage. We studied four adjacent sites in Alaska with varied permafrost regimes, including a black spruce forest on a peat plateau with permafrost, two collapse scar bogs of different ages formed following thermokarst, and a rich fen without permafrost. Measurements included year‐round eddy covariance estimates of net carbo...
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed
Rationale Viral illnesses in children are common and are frequently treated with antibiotic medication. Antibiotics reduce the diversity and composition of the gut microbiota, leading to poor developmental outcomes. Objectives To investigate the relationship between age at first exposure to antibiotics and cognitive and behavioural development at 4.5 years while controlling for multiple confounders, including otitis media. Met...
In the past, we generated transgenic mice that overexpress the human histamine 2 (H 2 )-receptor (H 2 -TG) or that overexpress the human serotonin 4 (5-HT 4 )-receptor (5-HT 4 -TG) in the heart. Here, we crossbred these lines of mice to generate double transgenic mice that overexpress both receptors (DT). This was done to study a conceivable interaction between these receptors in the mouse heart as a model for the human heart....
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