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Molecular Biology Reports · 2023 · Vol. 50 · Issue 12 · Springer
Background MicroRNA and cell-free DNA have shown significant correlations with several autoimmune disorders including systemic lupus erythematosus (SLE). SLE has been associated with challenges in determining its activity, so that the need for biomarkers contributing to assessing its activity is emerging. The current study investigated miRNA-21, miRNA-146a and plasma cf-DNA in determination of SLE activity, in addition their a...
Molecular Biology Reports · 2023 · Vol. 50 · Issue 11 · Springer
Aim This study aims to demonstrate the role of some inflammasomes genes: NLRC4 (the NLR family, CARD domain-containing protein 4), NLRP1 (NLR family, pyrin domain-containing 1), ASC (Apoptosis-associated speck-like protein containing a CARD), and CASPASE-1 in the pathogenesis of Rheumatoid arthritis (RA) in Egyptian population. Main methods The expression level of NLRC4, NLRP1, ASC, and CASPASE-1 within PBMCs isolated from all...