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The functional and molecular definition of progenitors giving rise to blood vessel endothelium in vivo remains disputed. Upon investigating the overlap of seemingly divergent reports currently defining putative endothelial progenitor cells (EPCs) using single-cell RNA-sequencing and flow cytometry, Protein C Receptor (PROCR) and Platelet-Derived Growth Factor Receptor Alpha (PDGFRA) largely overlapped with previously character...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Ensuring consistent data quality for environmental rating ecolabels with representative secondary datasetsNARA Subscribed
Purpose Environmental rating ecolabels (ERE) are developing rapidly across Europe, intending to guide sustainable purchasing choices through performance ratings derived from life cycle assessment (LCA). Integrating robust data quality methods in the LCA modelling stage is essential for accurate and comparable ratings, but challenging as ERE must be feasible to generate with reasonable effort for broad adoption. The use of seco...
Environmental rating ecolabels: How does product categorization affect product ratings and potential interpretation?NARA Subscribed
Environmental rating ecolabels (ERE) aim to present aggregated product environmental information to inform consumer choices. Performance ratings (e.g., A–E) are derived from life cycle assessment (LCA) results to enable comparison between products. The translation of LCA results to performance ratings requires definition of a common rating scale, either at a sector level or for subsets of products grouped by function (i.e., pr...
Warming of the Arctic due to climate change means the Arctic Ocean is now free from ice for longer, as sea ice melts earlier and refreezes later. Yet, it remains unclear how this extended ice-free period will impact carbon dioxide (CO2) fluxes due to scarcity of surface ocean CO2 measurements. Baseline measurements are urgently needed to understand spatial and temporal air–sea CO2 flux variability in the changing Arctic Ocean....
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
This paper describes a near-surface ocean profiler, which has been designed to precisely measure vertical gradients in the top 10 m of the ocean. Variations in the depth of seawater collection are minimized when using the profiler compared to conventional CTD/rosette deployments. The profiler consists of a remotely operated winch mounted on a tethered yet free-floating buoy, which is used to raise and lower a small frame housi...
Given that forests represent the primary terrestrial sink for atmospheric CO 2 , projections of future carbon (C) storage hinge on forest responses to climate variation. Models of gross primary production ( GPP ) responses to water stress are commonly based on remotely sensed changes in canopy ‘greenness’ (e.g., normalized difference vegetation index; NDVI ). However, many forests have low spectral sensitivity to water stress...
Chronic water stress reduces tree growth and the carbon sink of deciduous hardwood forestsNARA Subscribed
Predicted decreases in water availability across the temperate forest biome have the potential to offset gains in carbon (C) uptake from phenology trends, rising atmospheric CO 2 , and nitrogen deposition. While it is well established that severe droughts reduce the C sink of forests by inducing tree mortality, the impacts of mild but chronic water stress on forest phenology and physiology are largely unknown. We quantified th...
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