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Springer Nature1
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Pharmaceutical Research1
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20261
Robert B. Huizinga results 1 · Newest (Page 1/1, per page 25)
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Investigation of Renal Tissue Deposition of the Calcineurin Inhibitors Voclosporin, Cyclosporine and Tacrolimus Using MALDI-MSI ImagingNARA Subscribed
Pharmaceutical Research · 2026 · Vol. 43 · Issue 1 · Springer
Simon Zhou; Krishani Kumari Rajanayake; Miao He; Bo Wen; Ankhbayar Lkhagva; Ernie Yap; Duxin Sun; Jennifer Cross; Kory Engelke; Robert B. Huizinga
Background Calcineurin inhibitors (CNIs) are immunosuppressive agents that inhibit calcineurin (CN) and are recommended for the treatment of lupus nephritis (LN). In clinical trials, differences in the safety profiles of CNIs have been observed. Emerging data suggests that small molecule therapeutics may be differentially distributed and retained within organ tissues, potentially explaining these safety profile disparities. Me...
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