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Open Questions on Ion–Neutral Collisions and Coupling in the Lower Thermosphere–Ionosphere: Electrodynamics, Energetics and DynamicsNARA Subscribed
The Lower Thermosphere–Ionosphere (LTI) is the interface region between the Earth’s atmosphere and space. It is modulated by the energy and momentum deposition from the magnetosphere above and by the impacting waves from the lower atmosphere. The LTI region is defined by the co-existence and interaction of neutral and ionized species within the region’s electric and magnetic fields. This interplay results in unique and complex...
Upstate Abundance is a fresh market white-fleshed potato cultivar with resistance to both pathotypes Ro1 and Ro2 of the golden cyst nematode ( Globodera rostochiensis ) as well as to late blight ( Phytophthora infestans ) lineage US-23. It was selected from a cross made at Cornell University in 2000 between the Cornell breeding clone NY121 and the fresh-market cultivar Jacqueline Lee and released by the New York Agricultural E...
Bridging the Gap: Enhancing Prostate Cancer Survivorship and Advocacy Among Ethnically Diverse Black Men Through Community Town HallsNARA Subscribed
We present findings from town hall meetings held with ethnically diverse Black prostate cancer (CaP) survivors in 2022 and 2023. Four town halls (total participants, N = 265) focused on diagnosis, treatment, psychosocial support, and overall survivorship. Moderated by a long-term CaP survivor, each session featured a panel that included medical providers (urologic oncologists and clinical psychologists), as well as CaP survivo...
Myeloid-specific tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responsesNARA Subscribed
Background Proinflammatory mediators including COX-2, IL-1β, IL-6, and TNF-α, play major roles in the initiation of postsurgical pain. Produced primarily by activated macrophages and microglia, these mediators drive hyperexcitation of nociceptors and promote peripheral and central pain sensitization. Post-transcriptional RNA regulation is a major control point for these mediators, centering around adenine- and uridine-rich ele...
The Cost of Antivenom: A Cost Minimization Study using the North American Snakebite RegistryNARA Subscribed
Envenomation is a global health issue, with over 9,000 encounters managed in the United States yearly. The introduction of immunoglobulin fragment antivenom has reduced the risk of hypersensitivity. This study compares treatment costs of crotaline envenomation using the Fab and F(ab’) 2 antivenoms as reported to the North American Snakebite Registry (NASBR), a nationwide surveillance tool. Methods This was a retrospective anal...
Animals within social groups respond to costs and benefits of sociality by adjusting the proportion of time they spend in close proximity to other individuals in the group (cohesion). Variation in cohesion between individuals, in turn, shapes important group‐level processes such as subgroup formation and fission–fusion dynamics. Although critical to animal sociality, a comprehensive understanding of the factors influencing coh...
Understanding how species will respond to a rapidly changing global climate is requisite to conserving biodiversity. Though habitat losses from human development and land use change remain the most critical threats to biodiversity globally, some regions, such as low-lying islands, are particularly vulnerable to the effects of climate change. Despite this vulnerability, there may be opportunities for imperiled species on island...
Geography, environment, and colonization history interact with morph type to shape genomic variation in an Arctic fishNARA Subscribed
Polymorphic species are useful models for investigating the evolutionary processes driving diversification. Such processes include colonization history as well as contemporary selection, gene flow, and genetic drift, which can vary between intraspecific morphs as a function of their distinct life histories. The interactive and relative influence of such evolutionary processes on morph differentiation critically informs morph‐s...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Recruitment and growth rates for lake whitefish ( Coregonus clupeaformis ) inhabiting the Smallwood Reservoir, Labrador, Canada, were influenced by facets of its creation and the temporal variability in water levels associated with its operation. Filling of the reservoir between 1971 and 1974 created a concurrent increase in lake whitefish recruitment above long‐term averages. In addition, recruitment was influenced by winter...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...