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Unsupervised serious video games on the SmartMe&You home telemonitoring platform may enable the assessment of cognitive fluctuations in older individuals, with or without cognitive deficits. Here, we tested their validity in cognitively unimpaired older adults (Healthy) and patients with mild cognitive impairment and mild to moderate dementia due to Parkinson’s disease (PDCD). Such validity was assessed using Mini-Mental State...
Characterization of patient-derived intestinal organoids for modelling fibrosis in Inflammatory Bowel DiseaseNARA Subscribed
Background and aims Intestinal fibrosis is a common complication of Inflammatory Bowel Disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC), but the precise mechanism by which it occurs is incompletely understood hampering the development of effective therapeutic strategies. Here, we aimed at inducing and characterizing an inflammation-mediated fibrosis in patient-derived organoids (PDOs) issued from crypts i...
This work focuses on the modeling of a zero-emissions, high-speed catamaran ferry employing a full-electric propulsion system. It addresses the global emphasis on full-electric vessels to align with IMO regulations regarding ship emissions and energy efficiency improvement. Using the AVL Cruise-M software, this research verified the implementation of an onboard fuel cell power-generating system integrated with a propulsion pla...
From metabarcoding time series to plankton food webs: The hidden role of trophic hierarchy in providing ecological resilienceNARA Subscribed
The advent of metabarcoding (metaB) in aquatic ecology has provided a huge amount of information on plankton biodiversity worldwide. However, the large datasets obtained with that approach are still partially explored, especially for what concerns the study of trophic interactions and food webs. In this study, we analysed a metaB time series from the Long‐Term Ecological Research station MareChiara (LTER‐MC) in the Gulf of Nap...
Prevalence and clinical predictors of inappropriate direct oral anticoagulant dosage in octagenarians with atrial fibrillationNARA Subscribed
Purpose Older age is associated with inappropriate dose prescription of direct oral anticoagulants. The aim of our study was to describe the prevalence and the clinical predictors of inappropriate DOACs dosage among octogenarians in real-world setting. Methods Data for this study were sourced from the multicenter prospectively maintained Atrial Fibrillation (AF) Research Database (NCT03760874). Of the AF patients aged ≥ 80 who...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...