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Springer Nature1
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The AAPS Journal1
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20261
Roberto Visintainer results 1 · Newest (Page 1/1, per page 25)
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Predicting Aberrant Fc-fusion Protein Pharmacokinetics from In Silico Structural Properties and Physiologically Based Pharmacokinetic (PBPK) ModelingNARA Subscribed
The AAPS Journal · 2026 · Vol. 28 · Issue 3 · Springer
Danilo Tomasoni; Alessio Paris; Roberto Visintainer; Kevin D. Cook; Aochiu Chen; Isabel Figueroa; Veena A. Thomas; Luca Marchetti
The fusion of therapeutic proteins to the Fc domain of monoclonal antibodies (mAbs) generally improves the proteins' pharmacokinetic (PK) characteristics, extending in vivo half-lives due to the binding of the Fc domain to the FcRn receptor. Yet, several of these Fc-fusion biologics have been observed to have unexpected rapid clearance associated with non-specific off-target binding. Variability in non-specific clearance is of...
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