This pilot study evaluated the short- and mid-term outcomes of intra-articular allogeneic canine adipose-derived stem cell (ADSC) enriched secretome in dogs undergoing tibial plateau levelling osteotomy (TPLO), focusing on postsurgical recovery and osteoarthritis (OA) progression. Twenty client-owned dogs were randomly assigned ( n = 10 per group) to a control group (CG), receiving placebo, or a treated group (ADSC-Se), receiv...

A total of 221 tiger sharks ( Galeocerdo cuvier ) ranging from 82 to 426 cm total length (TL) were sampled off northeastern Brazil, including a vertebrally aged subsample of 67 individuals. Growth‐band counts ranged from 1 to 15, and agreement between readers was high (percentage error, %E = 2.1%). Marginal increment analysis did not reveal a consistent seasonal pattern in band deposition; therefore, band pairs were treated as...

Organotellurium (OTe) compounds have pharmacological properties, including leishmanicidal, antimalarial, and antifungal activities. Herein, we assessed cytotoxicity effects of OTe RF07 in a panel of tumor cell lines, as well as its oxidative, toxicity, and hemolytic actions. The toxicity was evaluated on Allium cepa and Artemia salina larvae. Cell viability was also assessed by resazurin in murine cells (Sarcoma 180), human ce...

Objective To evaluate whether patients with RLS have increased odds of ED compared with non-RLS controls. Methods We conducted a systematic review and meta-analysis analyzing the odds of ED in patients with RLS. We included studies that: (i) evaluated adults with a diagnosis of RLS established by the pre-established criteria; (ii) included a control group without RLS; and (iii) evaluated outcomes related to the odds of ED in p...

Oral squamous cell carcinoma (OSCC), accounts for approximately 90% of oral cancer cases, and due to its aggressive nature and limited treatment options remains a significant clinical challenge. In the pursuit of novel therapeutic agents, bis-chalcones (a subclass of chalcones) have emerged as promising candidates with multipronged anticancer potential. In this study, we synthesized and evaluated a novel bis-chalcone (B2OCH 3...

Introduction: Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder caused by pathogenic variants in CYP27A1 , leading to cholestanol accumulation and progressive neurological dysfunction. Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in several hereditary ataxias, but its role in CTX has not been investigated. We aimed to determine whether serum NfL is elevated in CTX and whether i...

Seed priming has emerged as a promising technique to improve seed germination and plant growth under water-limited conditions. However, a comprehensive understanding of the mechanisms involved in seed priming, particularly those related to post-dehydration processes and the subsequent acquisition of stress memory, remains limited. Thus, this study aimed to gain a better understanding of the effects of hydrogen peroxide (H 2 O...

In aquaculture practices, fish are mostly protected from lethal actions of predators. However, sub-lethal effects can be challenging to prevent, as they may be associated with chemical cues signaling predation risk that easily dissolve and spread in water, serving as potential stressors. These cues originate from predators, stressed or injured prey releasing blood, a conspecific alarm substance (CAS), and/or other bodily fluid...

Motivation Freshwater ecosystems have been heavily impacted by land‐use changes, but data syntheses on these impacts are still limited. Here, we compiled a global database encompassing 241 studies with species abundance data (from multiple biological groups and geographic locations) across sites with different land‐use categories. This compilation will be useful for addressing questions regarding land‐use change and its impact...