The microclimatic conditions within forests have great importance for biodiversity and ecosystem functioning. Consequently, understanding how management and associated changes in forest structure drive the inter-annual variability in forest microclimates is critical to forecasting ecosystem responses to climate change. Here, we investigated the impact of the amount of harvested timber on the inter-annual variability of forest...

Key message In Douglas-fir grown in Central Europe, growth and specific leaf area differed between coastal and interior provenances but little intra-specific variability was found for the Huber value and xylem safety. Abstract In Central Europe, the economically most important timber species for roundwood production, Norway spruce, has been severely affected by recent global change-type drought events. Due to its large spatial...

Purpose The potent, selective phosphodiesterase-9A inhibitor BI 409306 may be beneficial for patients with attenuated psychosis syndrome and could prevent relapse in patients with schizophrenia. Transient BI 409306-dependent increases in heart rate (HR) demonstrated previously necessitated cardiac safety characterisation. We evaluated cardiac effects of BI 409306 in healthy volunteers during rest and exercise. Methods In this...

Unprecedented tree dieback across Central Europe caused by recent global change‐type drought events highlights the need for a better mechanistic understanding of drought‐induced tree mortality. Although numerous physiological risk factors have been identified, the importance of two principal mechanisms, hydraulic failure and carbon starvation, is still debated. It further remains largely unresolved how the local neighborhood c...

Xylem embolism resistance has been identified as a key trait with a causal relation to drought-induced tree mortality, but not much is known about its intra-specific trait variability (ITV) in dependence on environmental variation. We measured xylem safety and efficiency in 300 European beech (F agus sylvatica L.) trees across 30 sites in Central Europe, covering a precipitation reduction from 886 to 522 mm year −1 . A broad r...

Key message By combining dendrochronological time-series analysis with radial vessel features, we show that the reconstruction of hydraulic properties improves our understanding of tree species’ acclimation potential to climate change. Abstract The vascular architecture plays a crucial role in the productivity and drought tolerance of broadleaf trees, but it is not yet fully understood how the hydraulic system is acclimating t...