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Informatics for toxicokineticsNARA Subscribed
Introduction Seabirds and other insular birds are an important part of marine ecosystems and are increasingly threatened worldwide. Phenology, abundance, distribution, and breeding success are important baseline parameters needed to evaluate population trends and dynamics, identify biodiversity hotspots and potential breeding sites, and assess habitat selection. In the Red Sea basin, reliable and complete data on birds are lac...
The authors investigated left–right turning preferences of n = 260 juvenile European sea bass ( Dicentrarchus labrax ) reared in ambient conditions and ocean acidification (OA) conditions or in ambient conditions but tested in OA water. Groups of 10 individuals were observed alone in a circular tank, and individuals' left and right turning during free‐swimming was quantified using trajectory data from the video. The authors sh...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Neurotoxicity of Tityus bahiensis (brown scorpion) venom in sympathetic vas deferens preparations and neuronal cellsNARA Subscribed
Systemic scorpion envenomation is characterized by massive neurotransmitter release from peripheral nerves mediated primarily by scorpion venoms neurotoxins. Tityus bahiensis is one of the medically most important species in Brazil, but its venom pharmacology, especially regarding to peripheral nervous system, is poorly understood. Here, we evaluated the T. bahiensis venom activity on autonomic (sympathetic) neurotransmission...
Motivation The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community‐led open‐source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal...
Whole‐genome resequencing uncovers molecular signatures of natural and sexual selection in wild bighorn sheepNARA Subscribed
The identification of genes influencing fitness is central to our understanding of the genetic basis of adaptation and how it shapes phenotypic variation in wild populations. Here, we used whole‐genome resequencing of wild Rocky Mountain bighorn sheep ( Ovis canadensis ) to >50‐fold coverage to identify 2.8 million single nucleotide polymorphisms ( SNP s) and genomic regions bearing signatures of directional selection (i.e. se...
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