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FOXG1 Transcriptionally Orchestrates Parvalbumin+ Interneuron Function Contributing to Schizophrenia PathologyNARA Subscribed
Schizophrenia (SCZ) is characterized by heterogeneous symptoms including abnormal perception, social withdrawal, and cognitive deficits. Parvalbumin-positive (PV + ) interneurons are particularly vulnerable in SCZ; however, the underlying cellular basis remains unclear. In this study, we found that selective deletion of the SCZ risk gene Foxg1 in PV + interneurons of mice recapitulated aspects of the disease phenotype, includi...
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