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Bridging Aquaculture and Human Medicine: A Comprehensive Review of Zebrafish Models for Chronic Kidney DiseaseNARA Subscribed
Chronic kidney disease (CKD) poses a significant global health burden, necessitating robust animal models for mechanistic studies and drug discovery. Zebrafish offers unique advantages as a powerful models in kidney disease, including high‐throughput compatibility, optical transparency, and significant genetic and nephron homology with both humans and farmed teleosts. However, challenges, such as the species' potent regenerati...
Under the current global biodiversity crisis, there is a need for automated and noninvasive monitoring techniques that can gather large amounts of data cost‐effectively at various ecological scales, from local to large spatial scales. These data can then be analyzed to inform stakeholders and decision‐makers. One such technique is passive acoustic monitoring, which is commonly coupled with automatic identification of animal sp...
Ndufa4 Regulates the Proliferation and Apoptosis of Neurons via miR-145a-5p/Homer1/Ccnd2NARA Subscribed
The Dandy–Walker malformation (DWM) is characterized by neuron dysregulation in embryonic development; however, the regulatory mechanisms associated with it are unclear. This study aimed to investigate the role of NADH dehydrogenase 1 alpha subcomplex 4 (NDUFA4) in regulating downstream signaling cascades and neuronal proliferation and apoptosis. Ndufa4 overexpression promoted the proliferation of neurons and inhibited their a...
Most studies of whether and how nanoparticles (NPs) affect antibiotic resistance genes (ARGs) focus on testing single NPs type. In this study, we determined the combined effect of Cu- and ZnO- NPs in the water samples collected from the Yangtze River Estuary and found the effect differs greatly from that produced by individual NPs. The results showed that the Cu- and ZnO- NPs co-exposure resulted in an enrichment of ARGs, wher...