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NARA Subscribed1
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Springer Nature1
Journal
European Journal of Clinical Pharmacology1
Publication Year
20221
Rucha Sane results 1 · Newest (Page 1/1, per page 25)
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Author: Rucha Sane ×Clear All Filters
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The effect of BI 409306 on heart rate in healthy volunteers: a randomised, double-blind, placebo-controlled, crossover studyNARA Subscribed
European Journal of Clinical Pharmacology · 2022 · Vol. 78 · Issue 5 · Springer
Fabian Müller; Michael Sand; Glen Wunderlich; Jasmin Link; Christian Schultheis; Chantaratsamon Dansirikul; Rucha Sane; Roman Laszlo; Jürgen M. Steinacker
Purpose The potent, selective phosphodiesterase-9A inhibitor BI 409306 may be beneficial for patients with attenuated psychosis syndrome and could prevent relapse in patients with schizophrenia. Transient BI 409306-dependent increases in heart rate (HR) demonstrated previously necessitated cardiac safety characterisation. We evaluated cardiac effects of BI 409306 in healthy volunteers during rest and exercise. Methods In this...
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