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The impact of genetic variants of the IGF-1 axis on surgical outcomes and prognosis in ovarian cancerNARA Subscribed
Background Ovarian cancer (OC) remains the most lethal gynaecological malignancy, largely due to late-stage diagnosis, tumour heterogeneity, and high recurrence rates. The insulin-like growth factor-1 (IGF-1) axis has been implicated in tumour proliferation, survival, and treatment resistance. Yet, the prognostic relevance of its genetic variants in OC is not well established. The present study aims to evaluate the impact of t...
Resistance of melon genotypes to Meloidogyne incognita and M. javanica: an approach based on genetic parameters estimated via REML/BLUPNARA Subscribed
Melon is one of the main vegetable crops grown in Brazil and is severely affected by root-knot nematodes of the genus Meloidogyne . The identification of resistance sources is therefore essential. Estimates of genetic parameters in breeding programs provide insight into the effects underlying the traits under evaluation. The objective of this study was to identify melon accessions resistant to Meloidogyne incognita and M. java...
A hybrid framework to estimate live fuel moisture content through land surface modellingNARA Subscribed
Wildfires are among the most powerful natural phenomena that have severe environmental and social impacts. Their increasing frequency and intensity, driven by climate change and unsustainable land-use practices, emphasise the importance of reliable fire risk assessment tools. Live fuel moisture content (LFMC) is a key variable for wildfire risk assessment and management, as it directly influences fire behaviour and propagation...
Numerical simulation of the shake-table response of a U-shaped RC wall using the Applied Element MethodNARA Subscribed
The Applied Element Method (AEM) has in the recent years been increasingly employed to assess the failure mechanisms developed by structures subjected to dynamic loading. However, its use in the detailed estimation of local response parameters such as strains, curvature, and other localised deformations of reinforced concrete (RC) elements under seismic excitation, is not common. In this context, we explore the feasibility of...
The Seaward Migration of European Eel at a Continental Scale: A Europe‐Wide Biotelemetry Meta‐AnalysisNARA Subscribed
The European eel ( Anguilla anguilla L.) has a catadromous life cycle, with a single panmictic population that colonises continental Europe and northern Africa yet migrates 5000 to 9000 km to spawn in the Atlantic Ocean. It is unknown how this continental migration is organised so individual eels arrive in time for spawning with conspecifics. This meta‐analysis combined tracking data from 18 water bodies in freshwater and tran...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Morphological and Molecular Profiling of Amyloid-β Species in Alzheimer’s PathogenesisNARA Subscribed
Alzheimer’s disease (AD) is the most common form of dementia around the world (~ 65%). Here, we portray the neuropathology of AD, biomarkers, and classification of amyloid plaques (diffuse, non-cored, dense core, compact). Tau pathology and its involvement with Aβ plaques and cell death are discussed. Amyloid cascade hypotheses, aggregation mechanisms, and molecular species formed in vitro and in vivo (on- and off-pathways) ar...