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The impact of genetic variants of the IGF-1 axis on surgical outcomes and prognosis in ovarian cancerNARA Subscribed
Background Ovarian cancer (OC) remains the most lethal gynaecological malignancy, largely due to late-stage diagnosis, tumour heterogeneity, and high recurrence rates. The insulin-like growth factor-1 (IGF-1) axis has been implicated in tumour proliferation, survival, and treatment resistance. Yet, the prognostic relevance of its genetic variants in OC is not well established. The present study aims to evaluate the impact of t...
Conventional bivalve depuration protocols may compromise organoleptic and nutritional quality, largely as a consequence of fasting. This study investigates an innovative post-depuration feeding strategy in the clam Ruditapes decussatus using microencapsulated diets containing Nannochloropsis sp. supplemented with either a standard dose of vitamins C and E (MV) or a high dose—4× the standard level—of these vitamins (MV+). A thr...
In vivo evaluation of the anti-inflammatory efficacy of liposomes loaded with Echinacea purpurea roots extractsNARA Subscribed
WHO ranked chronic inflammatory diseases as the most significant cause of death. The current therapeutic approach is the constant administration of clinically available anti-inflammatory drugs; however, this strategy presents severe side effects. New entities derived from plants have shown their potential for developing safe and effective therapies. Particularly, Echinacea purpurea extracts have demonstrated strong anti-inflam...
Floating debris dynamics in a tidal strait: transport and retention in Sundklakkstraumen, LofotenOA Marine
Understanding the transport and retention of floating plastic debris in fjords and coastal systems is essential for targeted mitigation strategies. This study investigates surface transport dynamics in Storvika and Sundklakkstraumen, a tidally energetic system in the Lofoten archipelago, Northern Norway. We combine GPS-tracked drifter observations with high-resolution 2D and 3D hydrodynamic modeling to assess how tidal forcing...
The northeast Atlantic Ocean contains multiple habitats considered critical for shark conservation, including nursery areas, migratory corridors and aggregation sites. In this context, updating knowledge on shark diversity and the threats affecting them in this region is essential to defining priorities and implementing the right management and conservation measures. Here, we show that Cabo Verde, Canarias, Madeira and Azores...
MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugalNARA Subscribed
Mammals are threatened worldwide, with ~26% of all species being included in the IUCN threatened categories. This overall pattern is primarily associated with habitat loss or degradation, and human persecution for terrestrial mammals, and pollution, open net fishing, climate change, and prey depletion for marine mammals. Mammals play a key role in maintaining ecosystems functionality and resilience, and therefore information o...
Demosponges are a well-known source of a plethora of bioactive compounds. In particular, they are able to form a skeleton by direct deposition of silica in a process catalyzed by silicatein. Herein, we isolated biosilicas from five different Atlantic deep-sea sponges Geodia atlantica (GA), Geodia barretti (GB), Stelletta normani (SN), Axinella infundibuliformis (AI), and Phakellia ventilabrum (PV) to explore the bioactivity an...
An experimental life support system ( ELSS ) was constructed to study the interactive effects of multiple stressors on coastal and estuarine benthic communities, specifically perturbations driven by global climate change and anthropogenic environmental contamination. The ELSS allows researchers to control salinity, pH , temperature, ultraviolet radiation ( UVR ), tidal rhythms and exposure to selected contaminants. Unlike most...