Purpose The European Medicines Agency (EMA) guideline Declaration of Storage Conditions in the Product Information of Medicinal Products (CPMP/QWP/609/96/Rev.2) was last revised in 2007. Since then, advances in stability science, increased climatic variability, and evolving regulatory expectations have highlighted limitations in the framework, particularly the use of vague descriptors such as “room temperature” or “no special...

Alzheimer’s disease (AD) is the most common form of dementia around the world (~ 65%). Here, we portray the neuropathology of AD, biomarkers, and classification of amyloid plaques (diffuse, non-cored, dense core, compact). Tau pathology and its involvement with Aβ plaques and cell death are discussed. Amyloid cascade hypotheses, aggregation mechanisms, and molecular species formed in vitro and in vivo (on- and off-pathways) ar...

The marine ornamental fish trade ( MOFT ) is a worldwide industry that targets a remarkable quantity and diversity of reef fish species and provides an important source of revenue for exporting countries, particularly developing nations in Southeast Asia. Here we provide, for the first time, an economic assessment of the MOFT to the European Union ( EU ), one of the key players of the marine aquarium trade, along with the USA...