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Proteome profile analysis reveals regulatory mechanisms in the liver of Carassius auratus under short‐term salinity stress (10‰, 48 h)NARA Subscribed
Carassius auratus , a commercially important species in the ornamental aquarium industry, is sensitive to salinity fluctuations. In this study, 30 C. auratus of length 13.1 ± 2.9 cm and weight 103.8 ± 40.8 g/fish were placed into six plastic tanks (80 L) with five fish per tank. About 15 fish were exposed to 10‰ salinity for 48 h, while another 15 fish were kept in freshwater and continuously aerated (0‰) as a control. To inve...
Unveiling the “Glycolysis-Lactate-Lactylation” Axis: A Novel Target in Ischemic Cerebrovascular DiseaseNARA Subscribed
Ischemic cerebrovascular disease involves complex interactions between metabolic reprogramming and epigenetic regulation. Recent studies indicate that enhanced glycolysis and lactate accumulation under hypoxic conditions not only maintain cell viability by supplying energy but also participate in disease regulation through lactylation. Lactylation regulates gene expression, immune polarization, metabolic enzyme activity, and a...
Accelerating Sugarcane Breeding with Machine Learning: A Concurrent Multi-trait Predictive ApproachNARA Subscribed
A large and highly polyploid genome, long breeding cycles, low narrow-sense heritability of yield and its components, and persisting yield stagnation continue to challenge sugarcane variety improvement through both conventional and molecular breedings. To address this, this study developed an efficient phenotype-based concurrent multi-trait prediction framework using artificial intelligence, leveraging 2700 parent combinations...