Storm surge current-time estimations are strongly influenced by recent water-level conditions, while the temporal dependence among samples from the same typhoon event can complicate the assessment of model generalization to unseen events. This study evaluated storm surge estimation at the Lianyungang tide gauge using 2168 samples from 28 typhoon events during 2002–2024. A 41-feature extreme gradient boosting (XGBoost) model in...

Tension-leg platform (TLP) horizontal-axis wind turbines (TLP-HAWTs) have become increasingly important in deep-water offshore wind energy development. However, their performance is strongly affected by coupled platform motions induced by wind and wave loads, making fully coupled simulations a critical prerequisite for accurate performance assessment. Conventional fully coupled approaches often struggle to balance computationa...

This study aims to elucidate the biological effects of Baicalein (BA) on intervertebral disc degeneration (IDD) and the potential mechanisms involved. Network pharmacology analysis was performed to identify the core targets and signaling pathways responsible for the therapeutic effects of BA on IDD. In vitro validation was carried out using IL-1β-stimulated nucleus pulposus cells (NPCs). Cell viability, apoptosis, inflammatory...

Yawning coupled with penile erection is a conserved neurobehavioral syndrome mediated by the paraventricular hypothalamus (PVH). However, the distinct roles of oxytocin and its co-transmitters remain unresolved. Using chemogenetics, we showed that activation of PVH oxytocin neurons was sufficient to elicit both responses, whereas silencing these neurons abolished them. Viral tracing revealed that these neurons project collater...

Biomolecular condensates formed through phase separation have emerged as a central principle of cellular organization, enabling the dynamic regulation of gene expression, signaling, metabolism, and stress responses. While early conceptual advances in condensate biology have largely originated from animal and in vitro systems, plant cells present a unique set of biological and technical challenges, including rigid cell walls, t...

Decapod iridovirus 1 (DIV1) is a highly lethal pathogen that infects decapod crustaceans including Litopenaeus vannamei , causing mass mortality in cultured shrimp and severe economic losses worldwide. The ATPase gene is a highly conserved region within the DIV1 genome, plays a critical role in viral replication and represents an ideal target for molecular diagnostic development. In this study, we established a rapid, sensitiv...