The lateral hypothalamic area (LHA) plays a pivotal role in regulating consciousness transition, in which orexinergic neurons, GABAergic neurons, and melanin-concentrating hormone neurons are involved. Glutamatergic neurons have a large population in the LHA, but their anesthesia-related effect has not been explored. Here, we found that genetic ablation of LHA glutamatergic neurons shortened the induction time and prolonged th...

Suction caissons are widely used foundations in offshore engineering. The change in excess pore pressure and seepage field caused by penetration and suction significantly affects the soil resistance around the caisson wall and tip, and also affects the deformation of the soil within and adjacent to the caisson. This study uses Arbitrary Lagrangian–Eulerian (ALE) large deformation solid-fluid coupled FEM to investigate the chan...