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Introduction Short-chain chlorinated paraffins (SCCPs) have garnered increased attention due to higher persistence, bioaccumulation, long-distance transportation potential, and heightened toxicity to aquatic species and mammals. Methods This paper evaluated the toxic effects of SCCPs on P. tricornutum during a 96-hour acute exposure experiment, focusing on growth inhibition, photosynthetic parameters, and oxidative stress resp...
Sub-sag 21 in the eastern Yangjiang Sag, Pearl River Mouth Basin, South China, contains a thick lacustrine source-rock interval within the lower Wenchang Formation and is a major exploration target on the northern margin of the South China Sea. However, the timing of deposition during the early to middle Eocene remains poorly constrained, and the applicability of quantitative palaeoclimate reconstruction methods in low-latitud...
Unveiling the “Glycolysis-Lactate-Lactylation” Axis: A Novel Target in Ischemic Cerebrovascular DiseaseNARA Subscribed
Ischemic cerebrovascular disease involves complex interactions between metabolic reprogramming and epigenetic regulation. Recent studies indicate that enhanced glycolysis and lactate accumulation under hypoxic conditions not only maintain cell viability by supplying energy but also participate in disease regulation through lactylation. Lactylation regulates gene expression, immune polarization, metabolic enzyme activity, and a...