Purpose Cerebral palsy (CP) is typically associated with abnormal gait that may alter knee joint loading and accelerate joint degeneration. We developed an integrated musculoskeletal-finite element (MSK-FE) framework to quantify differences in knee joint biomechanics between children with CP and typically developing (TD) peers. Methods Gait data from 13 children (TD, n = 5; hemiplegia [HP], n = 4; diplegia [DP], n = 4) were an...