Improving cognitively healthy survival is important for achieving healthy aging. Therefore, it would be valuable to estimate the future risk of either incident dementia or death in community-dwelling older adults. This study aimed to develop a set of risk prediction models for either incident dementia or death that can be applied according to data availability across diverse clinical settings, using longitudinal data from comm...

In most vertebrates, males and females display distinct reproductive behaviors. Some fish can change their sexual phenotype at various life stages, which involves alterations in their gonadal sex and changes in their reproductive behavior to align with the new gonadal identity. Although the sex reversal phenomenon in reproductive behavior is well documented, the underlying mechanisms in the brains of these fish remain largely...

Diet is widely considered essential in dementia, but its association with white matter lesions (WMLs) remains unclear. This cross-sectional study investigated the associations between dietary patterns, dementia, and WMLs in a large, nationwide, multicenter population of older Japanese adults. A total of 8,938 adults (aged ≥ 65; 73 ± 6.3 years old) from the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD...

Asian rice ( Oryza sativa ) was domesticated from O. rufipogon , and reduced seed-shattering behaviour was selected to increase yields. Two seed-shattering loci, qSH3 and sh4 , are involved in reducing seed shattering in both japonica and indica rice cultivars, while qSH1 and qCSS3 are likely specific to japonica cultivars. In indica cultivars, qSH3 and sh4 fail to explain the degree of seed shattering, as an introgression lin...

Recurring outbreaks of crown-of-thorns starfish (COTS) severely damage healthy corals, especially in the Western Pacific Ocean. To obtain a better understanding of population genetics of COTS and historical colonization across the Pacific Ocean, complete mitochondrial genomes were sequenced from 243 individuals collected in 11 reef regions. Our results indicate that Pacific COTS ( Acanthaster cf. solaris ) comprise two major c...

The prevalence of sleep-disordered breathing (SDB) is reportedly very high. Among SDBs, the incidence of obstructive sleep apnea (OSA) is higher than previously believed, with patients having moderate-to-severe OSA accounting for approximately 20% of adult males and 10% of postmenopausal women not only in Western countries but also in Eastern countries, including Japan. Since 1998, when health insurance coverage became availab...