Nicotinamide N-methyltransferase (NNMT) is an S-adenosyl-l-methionine (SAM)-dependent cytosolic enzyme, and a growing body of evidence suggest that it plays an essential role in cancer progression. Recently, NNMT has a role in methylation metabolism and tumorigenesis and was associated with a poor prognosis against numerous cancers. In addition, it has been reported that NNMT has been overexpressed in the stroma of advanced hi...

Studying subduction zone fluid at shallow seismogenic depths is important to understand the nature of fault rocks at the updip limit of the seismogenic zone because fluid–rock interactions affect heat and mass transfer, and fault strength. In this study, we conducted detailed analyses of distribution of shear veins, and estimation of pressure–temperature conditions for shear vein formation for the Yokonami mélange, Shikoku, So...