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Deviations from additivity in APOE4-mediated late-onset Alzheimer’s disease risk across races and ethnicitiesNARA Subscribed
APOE ’s ε4 haplotype ( APOE4 ) is late onset Alzheimer’s disease’s (LOAD) strongest genetic risk factor. Therefore, accurately modeling APOE4 ’s effect is critical to understanding LOAD. This is especially important as APOE4 odds ratios (OR) vary across racial and ethnic (R/E) groups. We analyzed the APOE4 -LOAD association in 3,196 East Asian, 31,105 non-Hispanic White (White), 1,646 Hispanic and Latino (Hispanic), and 6,068...
Periodical cicada ( Magicicada spp.) ranges have continued to decline even as their habitat has rebounded from historic lows. This counterintuitive trajectory may be a consequence of Magicicada 's limited dispersal capabilities combined with their requirement that individual host trees survive across decades. Indeed, we find that the presence of Magicicada breeding populations is best predicted by tree cover in 1930, not by pr...
Conservation practitioners face the complex challenge of addressing global biodiversity threats within social-ecological systems with multiple jurisdictions, numerous interest groups, and changing environmental conditions. Bridging the research-to-implementation gap between scientists and managers, which integrates diverse perspectives that represent the variety of considerations impacting management outcomes can help to infor...
High Site Fidelity and Elevated δ¹⁵N in Bonefish (Albula vulpes) Suggest Localized Wastewater Stress in a Marine National ParkNARA Subscribed
Coastal zones are subjected to many anthropogenic stresses that operate on multiple spatial scales. Understanding how these stressors interact with the movement and resource ecology of mobile species is critical for effective conservation and management. Biscayne National Park (BNP) is adjacent to Miami (U.S.) and supports an economically important recreational fishery for bonefish ( Albula vulpes ). Within BNP, the western re...