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Farnesyltransferase inhibitors decrease matrix-vesicle-mediated mineralization in SaOS-2 cellsNARA Subscribed
Background Farnesyltransferase inhibitors (FTIs) were developed for preventing the prenylation of aberrant Ras in human cancer. Furthermore, prenylation is involved in multiple biological processes and plays a putative role in signalling pathways such as the Ras-mitogen-activated-protein kinase (MAPK) pathway. Matrix-vesicle-mediated mineralization (MVM) is the first step in the development of eukaryotic mineralized tissue. In...
Shape from spectraNARA Subscribed
Diuretics: a contemporary pharmacological classification?NARA Subscribed
Diuretics are drugs that increase the flow of urine. They are commonly used to treat edema, hypertension, and heart failure. Typically, the pharmacological group consists of five classes: thiazide diuretics, loop diuretics, potassium-sparing diuretics, osmotic diuretics, and carbonic anhydrase inhibitors. This traditional classification and the nomenclature of diuretics have not changed over the last decades, which means that...
HMG-CoA-Reductase inhibitors (HMGRIs) are currently the most widely used group of drugs in patients with coronary artery disease (CAD) and are given preemptively to patients with high levels of cholesterol, including those with diabetes mellitus (DM). However, intake of HMGRIs also increases the progression of coronary artery calcification (CAC) and the risk of developing DM. This study aimed to investigate whether HMGRI intak...
Obsidian pyroclasts in the Yellowstone-Snake River Plain ignimbrites are dominantly juvenile in originNARA Subscribed
Dense, glassy pyroclasts found in products of explosive eruptions are commonly employed to investigate volcanic conduit processes through measurement of their volatile inventories. This approach rests upon the tacit assumption that the obsidian clasts are juvenile, that is, genetically related to the erupting magma. Pyroclastic deposits within the Yellowstone-Snake River Plain province almost without exception contain dense, g...
AktuellNARA Subscribed