Rationale Delta-9-tetrahydrocannabinol (Δ9-THC) has been reported to evoke psychedelic-like experiences at high doses in some individuals. However, the doses of Δ9-THC that occasion such effects and the phenomenology of these experiences are poorly understood. Objectives This brief report presents preliminary findings from a pilot human laboratory study that directly compared the acute effects of Δ9-THC and psilocybin under se...

Gravitational volcanic flank collapses are recurrent processes producing large-scale landslides, commonly associated with secondary instabilities and destructive tsunamis. Ocean island volcanoes are particularly prone to such failures, yet the dynamics, emplacement mechanisms, and tsunamigenic potential of gravitational collapses remain poorly constrained due to the scarcity of direct observations. The ~ 68 ka Monte Amarelo fl...

Background Psilocybin is among the serotonergic psychedelics closest to potential FDA approval, with growing evidence of therapeutic benefit across psychiatric conditions. As clinical trials expand, systematic characterization of adverse events (AEs) remains essential. While transient hypertensive responses are well documented, hypotensive events such as neurocardiogenic syncope (NCS) are rarely reported. Case presentation We...

Coastal communities worldwide face accelerating risks from sea-level rise and intensifying storms, yet many lack the capacity and framework needed to adapt. ResilientWoodsHole ( RWH ), a private–public partnership in the low-lying scientific village of Woods Hole, Massachusetts, offers lessons learned and practical strategies for how small communities can meet this challenge. Bringing together thirteen partners, including Wood...

Reliable predictions of species responses to intensifying temperature extremes are crucial for managing climate change impacts. However, limited data of species' responses to heat stress across their distribution restricts prediction accuracy. Here we analyse three‐decades of kelp abundance observations in Australia, including cool to warm‐edge populations, relative to marine heatwaves (MHWs). As MHWs intensified, changes in k...

Drug development can take up to 15 years, costing as much as $11 billion USD, and relies heavily on high-quality data. The goal of this investigation of contract research organizations (CROs) was to assess the impact of data management activities (such as curation, quality assessment and integration) on model-informed drug development (MIDD) deliverables. A survey was sent to a diverse sample of CROs, to evaluate their baselin...