S. Bennett results 264
· Newest (Page 1/11, per page 25)
Author: S. Bennett ×Clear All Filters
Search Results
High‐Throughput Sequencing in Aquaculture Disease Investigations: Challenges and Opportunities for ImplementationNARA Subscribed
The current generation of sequencing technologies can produce terabases of data with exceptional accuracy and speed, at a fraction of the cost of older methods. Despite this unprecedented power, adoption into aquaculture health management presents several challenges, including identifying where such capability may be optimally deployed. Here we synthesise discussions from a structured expert workshop held at the 2025 Aotearoa...
Population genetics are routinely studied over vast geographical areas to address questions of origin, routes of migration and epidemiology. However, genetic diversity of certain microorganisms such as plant pathogenic fungi are difficult to study even on a small geographical scale due to their mixed reproduction systems, variable population sizes, clonality and versatility to host adaptation. The genetic variation of an econo...
Diatoms are a major phytoplankton group that plays a critical role in aquatic biogeochemical processes. Their metabolism relies on trace metals as cofactors for numerous enzymes, and changes in seawater pH may therefore influence metal sorption. Here, we investigated the effects of pH variability on diatom growth and trace‐metal sorption using neutron activation analysis (NAA). Although NAA has rarely been applied to phytoplan...
Radon is an established lung carcinogen, but more research is needed to inform whether area-based measures of radon exposure reflect underlying cancer risk. This study, the first of its kind in the UK, aimed to investigate the association between a nationwide indicative radon atlas and lung cancer risk in Northern Ireland, a region in which lung cancer screening programmes are under design. A population-based case–control stud...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Shallow seasonal stratification ameliorates coral bleaching during record-breaking marine heatwaves in a marginal subtropical systemNARA Subscribed
Marine heatwaves are intensifying globally, with the Fourth Global Coral Bleaching Event (GCBE) beginning in 2023, yet coral bleaching outcomes remain highly variable across space and time. This study examines the role of fine-scale thermal variation in shaping bleaching impacts during two record-breaking marine heatwaves (2022 and 2024) affecting shallow coral assemblages in the marginal and urbanised environments of Hong Kon...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The 4E-BPs as Translational Regulators in Neurological Disorders: Molecular Mechanisms and Therapeutic PotentialNARA Subscribed
Protein translation is essential for maintaining the optimal functioning of the human nervous system. The 4E-Binding proteins (4E-BPs) are central regulators of this process, acting on the initiation factor eIF4E. Three homologs 4E-BP1, 4E-BP2, and 4E-BP3, are differentially expressed, with the phosphorylation state controlling cap-dependent translation in response to diverse physiological inputs, including growth factors, cyt...
Reliable predictions of species responses to intensifying temperature extremes are crucial for managing climate change impacts. However, limited data of species' responses to heat stress across their distribution restricts prediction accuracy. Here we analyse three‐decades of kelp abundance observations in Australia, including cool to warm‐edge populations, relative to marine heatwaves (MHWs). As MHWs intensified, changes in k...
Stem rot, caused by the fungal pathogen Agroathelia rolfsii , is a devastating disease in peanut ( Arachis hypogaea L.), resulting in substantial global agricultural losses. This study employed RNA sequencing to unravel the molecular mechanisms of resistance by analysing the gene expression profiles of a resistant peanut genotype (Georgia-03 L) and a susceptible genotype (Valencia C) under normal and infected conditions. From...