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Climate change and invasive species both independently threaten marine biodiversity but can also interact. Invasive species often possess traits that not only promote their success in novel environments but may also confer resilience to climate‐driven ocean change, allowing them to respond favorably to a changing climate. Here, drawing on 67 studies across 30 non‐native species, we present moderate but consistent evidence that...
Expert consensus on passive heating interventions to promote skeletal muscle strength and mass: a delphi studyNARA Subscribed
Purpose Passive heating has emerged as a potential non‑exercise method to support muscle strength and mass, but its application is limited by inconsistent protocols and unclear dosage and safety guidelines. This study used a Delphi methodology to establish expert consensus on key parameters for passive heating interventions targeting neuromuscular and muscle morphology outcomes. Methods An international panel of academic exper...
Introduction Picocyanobacteria from the genera Prochlorococcus and Synechococcus thrive across the globe in aquatic environments, have relatively small genomes, and have growth dynamics regulated by both viral interactions and abiotic conditions, making them excellent model organisms for exploring host-pathogencoevolution. Methods We developed and refined methods to sample and sequence cyanobacteria, cyanophages, and measured...
Efficient Burial of Labile Organic Carbon in Sediments of Oxygenated Icelandic FjordsNARA Subscribed
Fjords are hotspots of organic carbon (OC) burial, making them key components in the global carbon cycle. Recent research shows high marine OC burial even under oxic fjord water columns, broadening the scope of key drivers of OC burial therein. Here, we investigate the fate of marine OC in fjord sediments underlying oxic bottom waters in East Iceland. We estimate OC sources using stable isotopes, degradation using chemical bio...
Effective Visualizations Using “vachette” to Assess and Communicate Pharmacometric Model ResultsNARA Subscribed
Using pharmacometrics to inform drug discovery and development decisions requires effective communication of models and data to all stakeholders. The new “vachette” visualization method presented here enables modelers and non-modelers to see how a model integrates and represents all data across relevant subgroups, showing how the model “sees” the data when it accounts for covariates. Vachette starts with user-provided model si...
The spread of antimicrobial resistance in the aquatic environment from faecal pollution: a scoping review of a multifaceted issueNARA Subscribed
Antimicrobial resistance (AMR) is a major global health concern accelerated by the misuse and mismanagement of antibiotics in clinical and veterinary settings, leading to longer treatment times, increased costs and greater mortality rates. The environment can play a major role as a source and disseminator of AMR, with faecal pollution, from both anthropogenic and non-anthropogenic sources making a significant contribution. The...
Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are associated with significant morbidity in survivors. While better and safer treatments for acute leukemia are urgently needed, standard drug development pipelines are lengthy and drug repurposing therefore provides a promising approach. Our previous evaluation of FDA-approved drugs for their antileukemic activity...
Continental shelf sediments are considered hotspots for nitrogen (N) removal. While most investigations have quantified denitrification in shelves receiving large amounts of anthropogenic nutrient supply, we lack insight into the key drivers of N removal on oligotrophic shelves. Here, we measured rates of N removal through denitrification and anammox by the revised‐isotope pairing technique (r‐IPT) along the Northeastern New Z...
Evaluation of oxytetracycline leaching from pregelatinized starch‐coated medicated fish feedNARA Subscribed
The rapid growth and intensification of aquaculture industries have led to an increased use of antibiotics. Consequently, growing concerns have mounted over the environmental contamination of these drugs from medicated feeds and the risk that this poses for antimicrobial resistance. To circumvent environmental leaching, farmers topcoat medicated feeds with oil; however, this only partially addresses the issue. This study inves...