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Interpreting Magnetic Anomalies in Dike Swarms: Deterministic and Probabilistic ApproachesNARA Subscribed
Magnetic anomaly-derived lineaments, indicative of major dike swarms at shallow crustal levels, are common features associated with igneous provinces due to the contrasting magnetisation of diabase and dolerite compared to crystalline and sedimentary country rocks. Aeromagnetic datasets are useful for tracking the extension of subsurface structures, but the observed magnetic anomalies rarely correspond directly to the exposed...
Biallelic germline MBD4 mutations predispose to colorectal polyposis, hypermutated AML, and schwannomasNARA Subscribed
Biallelic pathogenic variants in the MBD4 gene have recently been associated with an autosomal recessive cancer predisposition syndrome deemed “ MBD4 -associated neoplasia syndrome (MANS)”. Early reports of individuals with MANS highlight the propensity to develop young onset colorectal polyposis and hyper-mutated acute myeloid leukemia (AML). In the following case series, we present four patients with MANS from three families...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Nonstructural carbohydrate concentrations and root exudates shift in response to drought in almondsNARA Subscribed
Key message Under drought, carbohydrates initially increase in almond tree organs and, ultimately, their root exudates diversify, suggesting shifts in carbon dynamics may impact osmoregulation and exudation under stress. Abstract While root exudation allows trees to shape the rhizosphere, mobilize nutrients, and recruit beneficial microbes, it may be costly during abiotic stress like drought and be expected to decrease to cons...
Although cratons owe their longevity to thick, depleted and consequently buoyant sub-continental lithospheric mantle, their extents are commonly indicated by the known distribution of crustal rocks. However, the limits of a mapped cratonic area often do not match the seismically imaged thick sub-continental lithospheric mantle roots. New mantle xenolith petrology and geochemistry, combined with continental scale geophysical da...
Climate warming is changing tundra vegetation in the Arctic, with implications for plant litter properties. Warming may thus modify bacterial and fungal communities and their nitrogen (N) cycling capacity in the litter layer, which in turn can affect plant N availability. To address potential warming effects, we characterized the responses of bacterial and fungal communities and their genetically encoded capacity for inorganic...
Barth syndrome (BTHS) is an X-linked recessive disorder characterized by cardiomyopathy, skeletal muscle myopathy and fatigue, growth restriction, and neutropenia. Neutropenia increases the risk of life-threatening bacterial infections, a major cause of death in individuals with BTHS. Currently, there is no curative treatment for BTHS or associated neutropenia. The development of therapeutic strategies to correct BTHS-associat...
Purpose Despite growing research on Medicaid expansion’s impact on cancer outcomes, there remains a critical need for a more nuanced understanding of how expansion affects cancer care and survival. This study assesses whether Medicaid expansion was associated with improved receipt of standard treatment, timely treatment initiation, and overall survival among colon cancer patients, while examining the specific factors influenci...
Following rapid climate change, tundra plant communities are experiencing extensive compositional shifts. A conservation concern is the potential encroachment of boreal species into the tundra (‘borealisation’). Tundra borealisation has been sporadically reported, but not systematically quantified. Here, we synthesised data from across 32 study areas, spanning 1137 plots and 287 vascular plant species, resurveyed between 1981...
Coexistence, Extinction and Survival—The Evolutionary History of Bison Species in Western EurasiaNARA Subscribed
European bison ( Bison bonasus ) are one of the few European megafaunal species to survive the Late Pleistocene mass megafaunal extinction. Current conservation management efforts have proceeded in the absence of information about their evolutionary history, which has been obscured by recent severe population bottlenecks. We characterized mitochondrial genomes from 135 ancient bison samples spanning > 50,000 years (> 50 ka) ac...