When data are assimilated in a reservoir history matching problem, not all resulting models are equally reliable for forecasting the future behavior. Not only are many of the model assumptions incorrect, but the assimilation methods themselves are imperfect. In fact, even in the perfect model scenario in which all assumptions are correct, the data assimilation algorithm itself may be imperfect, and the posterior ensemble from...

Purpose of Review Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder characterized by hallucinations, delusions, paranoia, and anhedonia [1, 2]. Strong biological plausibility supports a disease-specific relationship between metal and metalloid exposures and SCZ, particularly through disruption of metal ion coordination within with the N-methyl-D-aspartate receptor (NMDAr), a key regulator of neurodevelopment and...

Islands with contrasting herbivore histories provide a natural framework to investigate the evolution of plant defenses. Theory predicts that on islands with historically intense vertebrate herbivory, juveniles maintain strong defenses while adults may reduce them once out of reach, whereas islands lacking vertebrate browsers show minimal ontogenetic differences and generally lower defenses. Alternatively, when extinct herbivo...

Down syndrome (DS), or trisomy 21 (T21), represents the most common genetic cause of intellectual disability worldwide and is associated with a wide range of medical, developmental, and neurodegenerative conditions, including a universal predisposition to early-onset Alzheimer’s disease (AD). Since its establishment in 2014, the Trisomy 21 Research Society (T21RS) has provided a global forum for advancing DS research across di...

Characterizing the genetic structure and connectivity between populations of endangered species can be used to inform management actions. In vagile species with high gene flow or recently established populations, such characterizations can be difficult to undertake using traditional genetic markers, and genetic stock identification (GSI) may be confounded by allele-sharing between populations. Loggerhead sea turtles ( Caretta...

Biogenic structural complexity is a key driver of biodiversity and ecosystem functioning, yet its ecological and environmental determinants remain poorly understood across broad biogeographic scales. Here, we conducted standardized 90‐day field experiments at 16 coastal sites, spanning a 41‐degree latitudinal gradient, using naturally assembled marine fouling communities on settlement panels. We measured rugosity as our metric...

A common approach to dealing with uncertainty when optimizing the expected value of a cost function is to perform the optimization of controls over an ensemble by simulating the outcome of the controls on each model realization. For reservoir management or reservoir field development optimization, this approach is very expensive, however, as the cost of each simulation is high. In this paper, a “mean model” methodology is prop...

Quantifying animal movements is necessary for answering a wide array of research questions in ecology and conservation biology. Consequently, ecologists have made considerable efforts to identify the best way to estimate an animal's home range, and many methods of estimating home ranges have arisen over the past half a century. Most of these methods fall into two distinct categories of estimators that have only recently been d...

The Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) initiative of the National Cancer Institute (NCI) supports long-standing collaborations between an under-resourced institution and NCI-designated Cancer Centers to strengthen cancer research workforce and advance cancer research capacity. One of the longest continuously funded CPACHE programs is the Morehouse School of Medicine/Tuskegee University/Universi...